| Function | Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery. Plays a role in mRNA export. (Microbial infection) Binds HIV-1 capsid-nucleocapsid (HIV-1 CA-NC) complexes and might thereby promote the integration of the virus in the nucleus of dividing cells (in vitro). |
| Protein Name | Cleavage And Polyadenylation Specificity Factor Subunit 6Cleavage And Polyadenylation Specificity Factor 68 Kda SubunitCpsf 68 Kda SubunitCleavage Factor Im Complex 68 Kda SubunitCfim68Pre-Mrna Cleavage Factor Im 68 Kda SubunitProtein Hpbrii-4/7 |
| Database Links | Reactome: R-HSA-1839117Reactome: R-HSA-5655302Reactome: R-HSA-72187Reactome: R-HSA-72203Reactome: R-HSA-73856Reactome: R-HSA-77595 |
| Cellular Localisation | NucleusNucleoplasmNucleus SpeckleCytoplasmShuttles Between The Nucleus And The Cytoplasm In A Transcription- And Xpo1/Crm1-Independent MannerMost Probably In Complex With The Cleavage Factor Im Complex (Cfim)Colocalizes With Pspc1 In Punctate Subnuclear Structures Often Located Adjacent To Nuclear SpecklesCalled ParaspecklesAnd Corresponding To Interchromatin Granules-Associated Zones (Igazs)Distribution In Speckles And Paraspeckles Varies During The Cell CycleAssociates At Sites Of Active Transcription On Nascent Perichromatin Fibrils (Pfs) And Perichromatin GranulesNuclear Import Is Mediated Via Interaction With Tnpo3 Independently Of Cpsf6 Phosphorylation Status |
| Alternative Protein Names | Cleavage And Polyadenylation Specificity Factor Subunit 6 proteinCleavage And Polyadenylation Specificity Factor 68 Kda Subunit proteinCpsf 68 Kda Subunit proteinCleavage Factor Im Complex 68 Kda Subunit proteinCfim68 proteinPre-Mrna Cleavage Factor Im 68 Kda Subunit proteinProtein Hpbrii-4/7 proteinCPSF6 proteinCFIM68 protein |
Information sourced from Uniprot.org
