• Biotinylated Human CDCP1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
  • The purity of Biotinylated Human CDCP1 is greater than 95% as determined by SEC-HPLC.
  • Immobilized Anti-CDCP1 Antibody, hFc Tag at 1 Mu g/ml (100 Mu l/Well) on the plate. Dose response curve for Biotinylated Human CDCP1, His Tag with the EC50 of 64. 8ng/ml determined by ELISA.

Human CDCP1 protein (Recombinant) (C-His-Avi) {Biotin} (STJP001666)

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STJP001666

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Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human CDCP1-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications.
Conjugation: Biotin
Formulation: Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Dilution Range: Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Storage Instruction: The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol: CDCP1
Gene ID: 64866
Uniprot ID: CDCP1_HUMAN
Immunogen Region: Phe30-Leu666
Immunogen: DNA sequence encoding Human CDCP1 including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
Post Translational Modifications Phosphorylated on tyrosine by kinases of the SRC family such as SRC and YES as well as by the protein kinase C gamma/PRKCG. Dephosphorylated by phosphotyrosine phosphatases. Also phosphorylated by suramin, a heparin analog. Tyrosine phosphorylated in response to dissociation of integrin alpha-6 beta-4 from laminin-5. N-glycosylated. A soluble form may also be produced by proteolytic cleavage at the cell surface (shedding). Another peptide of 80 kDa (p80) is present in cultured keratinocytes probably due to tryptic cleavage at an unidentified site on its N-terminal side. Converted to p80 by plasmin, a trypsin-like protease.
Function May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis.
Protein Name Cub Domain-Containing Protein 1
Membrane Glycoprotein Gp140
Subtractive Immunization M Plus Hep3-Associated 135 Kda Protein
Sima135
Transmembrane And Associated With Src Kinases
Cd Antigen Cd318
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Membrane Protein
Shedding May Also Lead To A Soluble Peptide
Isoform 3: Secreted
Alternative Protein Names Cub Domain-Containing Protein 1 protein
Membrane Glycoprotein Gp140 protein
Subtractive Immunization M Plus Hep3-Associated 135 Kda Protein protein
Sima135 protein
Transmembrane And Associated With Src Kinases protein
Cd Antigen Cd318 protein
CDCP1 protein
TRASK protein
UNQ2486 protein
PRO5773 protein

Information sourced from Uniprot.org

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