Human CD239/BCAM protein (Recombinant) (C-His) (STJP010119)

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STJP010119
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Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CD239/BCAM-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: BCAM
Gene ID: 4059
Uniprot ID: BCAM_HUMAN
Immunogen Region: Glu32-Glu148
Immunogen: Homo sapiens (Human)
Post Translational Modifications Epinephrine-stimulated phosphorylation of Ser-621 by PKA enhances adhesion to laminin. Ser-621 can also be phosphorylated by AKT1.
Function Transmembrane glycoprotein that functions as both a receptor and an adhesion molecule playing a crucial role in cell adhesion, motility, migration and invasion. Extracellular domain enables binding to extracellular matrix proteins, such as laminin, integrin and other ligands while its intracellular domain interacts with cytoskeletal proteins like hemoglobin, facilitating cell signal transduction. Serves as a receptor for laminin alpha-5/LAMA5 to promote cell adhesion. Mechanistically, JAK2 induces BCAM phosphorylation and activates its adhesion to laminin by stimulating a Rap1/AKT signaling pathway in the absence of EPOR.
Protein Name Basal Cell Adhesion Molecule
Auberger B Antigen
B-Cam Cell Surface Glycoprotein
F8/G253 Antigen
Lutheran Antigen
Lutheran Blood Group Glycoprotein
Cd Antigen Cd239
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Basal Cell Adhesion Molecule protein
Auberger B Antigen protein
B-Cam Cell Surface Glycoprotein
F8/G253 Antigen protein
Lutheran Antigen protein
Lutheran Blood Group Glycoprotein
Cd Antigen Cd239 protein
BCAM protein
LU protein
MSK19 protein

Information sourced from Uniprot.org

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