| Function | Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction. Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion.the costimulatory activity requires SH2D1A. Promotes recruitment of RORC to the IL-17 promoter. May be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response. May disable autoantibody responses and inhibit IFN-gamma secretion by CD4(+) T-cells. May negatively regulate the size of thymic innate CD8(+) T-cells and the development of invariant natural killer T (iNKT) cells. |
| Protein Name | T-Lymphocyte Surface Antigen Ly-9Cell Surface Molecule Ly-9Lymphocyte Antigen 9Slam Family Member 3Slamf3Signaling Lymphocytic Activation Molecule 3Cd Antigen Cd229 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinCell Membrane |
| Alternative Protein Names | T-Lymphocyte Surface Antigen Ly-9 proteinCell Surface Molecule Ly-9 proteinLymphocyte Antigen 9 proteinSlam Family Member 3 proteinSlamf3 proteinSignaling Lymphocytic Activation Molecule 3 proteinCd Antigen Cd229 proteinLY9 proteinCDABP0070 protein |
Information sourced from Uniprot.org
