||FOR RESEARCH USE ONLY (RUO).
||Recombinant-Human CD16a (FcgR3a)-protein was developed from hek293. For use in research applications.
||Recombinant CD16a is supplied as a 0.2 Mu m filtered PBS solution, pH7.2.
||A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL.
||Recombinant CD16a, as supplied, can be stored in working aliquots at 2-8°C for one month, or at-20°C to-70°C for twelve months. Avoid repeated freeze/thaw cycles.
||Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
| Tissue Specificity || Expressed on natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placental trophoblasts. |
| Post Translational Modifications || Glycosylated. Contains high mannose- and complex-type oligosaccharides. Glycosylation at Asn-180 is mandatory for high affinity binding to the Fc and for discrimination between fucosylated and afucosylated IgG glycoforms. The soluble form is produced by a proteolytic cleavage. |
| Function || Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis. |
| Protein Name || Low Affinity Immunoglobulin Gamma Fc Region Receptor Iii-ACd16a AntigenFc-Gamma Riii-AlphaFc-Gamma RiiiFc-Gamma RiiiaFcriiiFcriiiaFcr-10Igg Fc Receptor Iii-2Cd Antigen Cd16a |
| Database Links || Reactome: R-HSA-198933Reactome: R-HSA-2029481Reactome: R-HSA-2029482Reactome: R-HSA-2029485Reactome: R-HSA-9664323Reactome: R-HSA-9664422 |
| Cellular Localisation || Cell MembraneSingle-Pass Type I Membrane ProteinSecretedExists Also As A Soluble Receptor |
| Alternative Antibody Names || Anti-Low Affinity Immunoglobulin Gamma Fc Region Receptor Iii-A antibodyAnti-Cd16a Antigen antibodyAnti-Fc-Gamma Riii-Alpha antibodyAnti-Fc-Gamma Riii antibodyAnti-Fc-Gamma Riiia antibodyAnti-Fcriii antibodyAnti-Fcriiia antibodyAnti-Fcr-10 antibodyAnti-Igg Fc Receptor Iii-2 antibodyAnti-Cd Antigen Cd16a antibodyAnti-FCGR3A antibodyAnti-CD16A antibodyAnti-FCG3 antibodyAnti-FCGR3 antibodyAnti-IGFR3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance