| Tissue Specificity | Expression is restricted to functional NK and cytotoxic T lymphocytes. Expressed in viral-specific effector memory and terminally differentiated effector memory CD8+ T cells. Expressed in memory and activated CD4+ T cell subsets (at protein level). Expressed at high levels in intraepithelial lymphocytes (at protein level). Expressed in both alpha-beta and gamma-delta CD8+ T cell subsets (at protein level). Expressed in umbilical vein endothelial cells (at protein level). Expressed in monocytes and at lower levels in B cells. Isoform 3: Expressed exclusively in activated NK cells (at protein level). |
| Post Translational Modifications | |
| Function | CD160 antigen: Receptor on immune cells capable to deliver stimulatory or inhibitory signals that regulate cell activation and differentiation. Exists as a GPI-anchored and as a transmembrane form, each likely initiating distinct signaling pathways via phosphoinositol 3-kinase in activated NK cells and via LCK and CD247/CD3 zeta chain in activated T cells. Receptor for both classical and non-classical MHC class I molecules. In the context of acute viral infection, recognizes HLA-C and triggers NK cell cytotoxic activity, likely playing a role in anti-viral innate immune response. On CD8+ T cells, binds HLA-A2-B2M in complex with a viral peptide and provides a costimulatory signal to activated/memory T cells. Upon persistent antigen stimulation, such as occurs during chronic viral infection, may progressively inhibit TCR signaling in memory CD8+ T cells, contributing to T cell exhaustion. On endothelial cells, recognizes HLA-G and controls angiogenesis in immune privileged sites. Receptor or ligand for TNF superfamily member TNFRSF14, participating in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. Upon ligation of TNFRSF14, provides stimulatory signal to NK cells enhancing IFNG production and anti-tumor immune response. On activated CD4+ T cells, interacts with TNFRSF14 and down-regulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response. In the context of bacterial infection, acts as a ligand for TNFRSF14 on epithelial cells, triggering the production of antimicrobial proteins and pro-inflammatory cytokines. CD160 antigen, soluble form: The soluble GPI-cleaved form, usually released by activated lymphocytes, might play an immune regulatory role by limiting lymphocyte effector functions. |
| Protein Name | Cd160 AntigenNatural Killer Cell Receptor By55Cd Antigen Cd160 Cleaved Into - Cd160 Antigen - Soluble Form |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cd160 Antigen: Cell MembraneLipid-AnchorGpi-AnchorCd160 AntigenSoluble Form: SecretedReleased From The Cell Membrane By Gpi Cleavage |
| Alternative ELISA Names | Cd160 Antigen ELISA kitNatural Killer Cell Receptor By55 ELISA kitCd Antigen Cd160 Cleaved Into - Cd160 Antigen - Soluble Form ELISA kitCD160 ELISA kitBY55 ELISA kit |
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Information sourced from Uniprot.org
