| Post Translational Modifications | Degraded when the spindle assembly checkpoint is activated during the G2-M transition. Degradation depends on the C-terminal PEST sequence. Phosphorylated just before cells enter into mitosis. Ubiquitinated by the anaphase-promoting complex (APC/C).leading to its degradation by the proteasome. |
| Function | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The SCF(CCNF) E3 ubiquitin-protein ligase complex is an integral component of the ubiquitin proteasome system (UPS) and links proteasome degradation to the cell cycle. Mediates the substrate recognition and the proteasomal degradation of various target proteins involved in the regulation of cell cycle progression and in the maintenance of genome stability. Mediates the ubiquitination and proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. In G2, mediates the ubiquitination and subsequent degradation of ribonucleotide reductase RRM2, thereby maintaining a balanced pool of dNTPs and genome integrity. In G2, mediates the ubiquitination and proteasomal degradation of CDC6, thereby suppressing DNA re-replication and preventing genome instability. Involved in the ubiquitination and degradation of the substrate adapter CDH1 of the anaphase-promoting complex (APC/C), thereby acting as an antagonist of APC/C in regulating G1 progression and S phase entry. May play a role in the G2 cell cycle checkpoint control after DNA damage, possibly by promoting the ubiquitination of MYBL2/BMYB. |
| Protein Name | Cyclin-FF-Box Only Protein 1 |
| Database Links | Reactome: R-HSA-8951664Reactome: R-HSA-983168 |
| Cellular Localisation | NucleusCytoplasmPerinuclear RegionCytoskeletonMicrotubule Organizing CenterCentrosomeCentrioleLocalization To The Centrosome Is Rare In S Phase Cells And Increases In G2 CellsLocalizes To Both The Mother And Daughter CentriolesLocalization To Centrosomes Is Not Dependent On Cp110Localizes To The Nucleus In G2 Phase |
| Alternative Protein Names | Cyclin-F proteinF-Box Only Protein 1 proteinCCNF proteinFBX1 proteinFBXO1 protein |
Information sourced from Uniprot.org
