Human CASP10 protein (Recombinant) (N-His) (STJP005795)

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STJP005795
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CASP10-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: CASP10
Gene ID: 843
Uniprot ID: CASPA_HUMAN
Immunogen Region: Phe223-Ile459
Immunogen: Homo sapiens (Human)
Post Translational Modifications Cleavage by granzyme B and autocatalytic activity generate the two active subunits.
Function Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP8 and CASP9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. Isoform 7 can enhance NF-kappaB activity but promotes only slight apoptosis. Isoform C is proteolytically inactive.
Protein Name Caspase-10
Casp-10
Apoptotic Protease Mch-4
Fas-Associated Death Domain Protein Interleukin-1b-Converting Enzyme 2
Flice2
Ice-Like Apoptotic Protease 4 Cleaved Into - Caspase-10 Subunit P23/17 - Caspase-10 Subunit P12
Database Links Reactome: R-HSA-6803207
Reactome: R-HSA-75157
Reactome: R-HSA-75158
Reactome: R-HSA-933543
Alternative Protein Names Caspase-10 protein
Casp-10 protein
Apoptotic Protease Mch-4 protein
Fas-Associated Death Domain Protein Interleukin-1b-Converting Enzyme 2 protein
Flice2 protein
Ice-Like Apoptotic Protease 4 Cleaved Into - Caspase-10 Subunit P23/17 - Caspase-10 Subunit P12 protein
CASP10 protein
MCH4 protein

Information sourced from Uniprot.org

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