Human ATXN10 protein (Recombinant) (N-His) (STJP006124)

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STJP006124
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ATXN10-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: ATXN10
Gene ID: 25814
Uniprot ID: ATX10_HUMAN
Immunogen Region: Leu116-Ala302
Immunogen: Homo sapiens (Human)
Post Translational Modifications Polyubiquitinated. Phosphorylation at Ser-12 by AURKB promotes the association of ATXN10 with PLK1. Phosphorylation at Ser-77 and Thr-82 by PLK1 may play a role in the regulation of cytokinesis and may stimulate the proteasome-mediated degradation of ATXN10.
Function May play a role in the regulation of cytokinesis. May play a role in signaling by stimulating protein glycosylation. Induces neuritogenesis by activating the Ras-MAP kinase pathway and is necessary for the survival of cerebellar neurons. Does not appear to play a major role in ciliogenesis.
Protein Name Ataxin-10
Brain Protein E46 Homolog
Spinocerebellar Ataxia Type 10 Protein
Cellular Localisation Cytoplasm
Perinuclear Region
Midbody
Cytoskeleton
Cilium Basal Body
Microtubule Organizing Center
Centrosome
Centriole
Localizes To The Midbody During Telophase
Alternative Protein Names Ataxin-10 protein
Brain Protein E46 Homolog protein
Spinocerebellar Ataxia Type 10 Protein protein
ATXN10 protein
SCA10 protein

Information sourced from Uniprot.org

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