Function | Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme. |
Protein Name | Atpase Inhibitor - MitochondrialAtp Synthase F1 Subunit EpsilonInhibitor Of F(1f(O-AtpaseIf(1If1 |
Cellular Localisation | Mitochondrion |
Alternative Protein Names | Atpase Inhibitor - Mitochondrial proteinAtp Synthase F1 Subunit Epsilon proteinInhibitor Of F(1f(O-Atpase proteinIf(1 proteinIf1 proteinATP5IF1 proteinATPI proteinATPIF1 protein |
Information sourced from Uniprot.org