| Post Translational Modifications | During unfolded protein response, a fragment of approximately 50 kDa containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 (MBTPS1, S1P) and site-2 (MBTPS2, S2P) proteases. N-glycosylated. The glycosylation status may serve as a sensor for ER homeostasis, resulting in ATF6 activation to trigger the unfolded protein response (UPR). Ubiquitinated by RNF186 at Lys-152, which is required for pattern recognition receptor-induced unfolded protein response-associated outcomes. |
| Function | Cyclic AMP-dependent transcription factor ATF-6 alpha: Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 alpha), which is embedded in the endoplasmic reticulum membrane. Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR). Processed cyclic AMP-dependent transcription factor ATF-6 alpha: Transcription factor that initiates the unfolded protein response (UPR) during endoplasmic reticulum stress by activating transcription of genes involved in the UPR. Binds DNA on the 5'-CCACGA-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCACGA-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina. |
| Protein Name | Cyclic Amp-Dependent Transcription Factor Atf-6 AlphaCamp-Dependent Transcription Factor Atf-6 AlphaActivating Transcription Factor 6 AlphaAtf6-Alpha Cleaved Into - Processed Cyclic Amp-Dependent Transcription Factor Atf-6 Alpha |
| Database Links | Reactome: R-HSA-380994Reactome: R-HSA-381033Reactome: R-HSA-381183 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane ProteinGolgi Apparatus MembraneTranslocates From The Endoplasmic Reticulum To The GolgiWhere It Is ProcessedProcessed Cyclic Amp-Dependent Transcription Factor Atf-6 Alpha: NucleusUnder Er Stress The Cleaved N-Terminal Cytoplasmic Domain Translocates Into The NucleusThbs4 Promotes Its Nuclear Shuttling |
| Alternative Protein Names | Cyclic Amp-Dependent Transcription Factor Atf-6 Alpha proteinCamp-Dependent Transcription Factor Atf-6 Alpha proteinActivating Transcription Factor 6 Alpha proteinAtf6-Alpha Cleaved Into - Processed Cyclic Amp-Dependent Transcription Factor Atf-6 Alpha proteinATF6 protein |
Information sourced from Uniprot.org
