Human ANP32B protein (Recombinant) (N-His) (STJP005782)

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STJP005782
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ANP32B-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: ANP32B
Gene ID: 10541
Uniprot ID: AN32B_HUMAN
Immunogen Region: Met1-Asp251
Immunogen: Homo sapiens (Human)
Post Translational Modifications Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group. Directly cleaved by caspase-3/CASP3.
Function Multifunctional protein that is involved in the regulation of many processes including cell proliferation, apoptosis, cell cycle progression or transcription. Regulates the proliferation of neuronal stem cells, differentiation of leukemic cells and progression from G1 to S phase of the cell cycle. As negative regulator of caspase-3-dependent apoptosis, may act as an antagonist of ANP32A in regulating tissue homeostasis. Exhibits histone chaperone properties, able to recruit histones to certain promoters, thus regulating the transcription of specific genes. Also plays an essential role in the nucleocytoplasmic transport of specific mRNAs via the uncommon nuclear mRNA export receptor XPO1/CRM1. Participates in the regulation of adequate adaptive immune responses by acting on mRNA expression and cell proliferation. (Microbial infection) Plays an essential role in influenza A and B viral genome replication. Also plays a role in foamy virus mRNA export from the nucleus to the cytoplasm.
Protein Name Acidic Leucine-Rich Nuclear Phosphoprotein 32 Family Member B
Acidic Protein Rich In Leucines
Putative Hla-Dr-Associated Protein I-2
Phapi2
Silver-Stainable Protein Ssp29
Cellular Localisation Isoform 1: Nucleus
Cytoplasm
Accumulates In The Nuclei At The S Phase
Isoform 2: Cytoplasm
Lacks A Nuclear Localization Signal
Alternative Protein Names Acidic Leucine-Rich Nuclear Phosphoprotein 32 Family Member B protein
Acidic Protein Rich In Leucines protein
Putative Hla-Dr-Associated Protein I-2 protein
Phapi2 protein
Silver-Stainable Protein Ssp29 protein
ANP32B protein
APRIL protein
PHAPI2 protein

Information sourced from Uniprot.org