Human AKR1A1 protein (Recombinant) (N-His) (STJP008742)

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STJP008742
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human AKR1A1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: AKR1A1
Gene ID: 10327
Uniprot ID: AK1A1_HUMAN
Immunogen Region: Met1-Tyr325
Immunogen: Homo sapiens (Human)
Function Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde. Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions and are cytotoxic. Involved also in the detoxification of lipid-derived aldehydes like acrolein. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN). Also acts as an inhibitor of protein S-nitrosylation by mediating degradation of S-nitroso-coenzyme A (S-nitroso-CoA), a cofactor required to S-nitrosylate proteins. S-nitroso-CoA reductase activity is involved in reprogramming intermediary metabolism in renal proximal tubules, notably by inhibiting protein S-nitrosylation of isoform 2 of PKM (PKM2). Also acts as a S-nitroso-glutathione reductase by catalyzing the NADPH-dependent reduction of S-nitrosoglutathione. Displays no reductase activity towards retinoids.
Protein Name Aldo-Keto Reductase Family 1 Member A1
Alcohol Dehydrogenase Nadp(+
Aldehyde Reductase
Glucuronate Reductase
Glucuronolactone Reductase
S-Nitroso-Coa Reductase
Scorr
Database Links Reactome: R-HSA-156590
Reactome: R-HSA-5661270
Cellular Localisation Cytoplasm
Cytosol
Apical Cell Membrane
Alternative Protein Names Aldo-Keto Reductase Family 1 Member A1 protein
Alcohol Dehydrogenase Nadp(+ protein
Aldehyde Reductase protein
Glucuronate Reductase protein
Glucuronolactone Reductase protein
S-Nitroso-Coa Reductase protein
Scorr protein
AKR1A1 protein
ALDR1 protein
ALR protein

Information sourced from Uniprot.org

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