Human AHRR (Aryl Hydrocarbon Receptor Repressor) Sandwich ELISA Kit Ready-To-Use Kit (STJE0013390)

Human AHRR (Aryl Hydrocarbon Receptor Repressor) Sandwich ELISA Kit Ready-To-Use Kit (STJE0013390)

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STJE0013390
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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.062ng/mL
Detection Limit: 0.156-10ng/mL
Short Description : This AHRR Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates, cell lysates or other biological fluids..
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: AHRR
Gene ID: 57491
Uniprot ID: AHRR_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Highly expressed in testis, lung, ovary, spleen and pancreas. Highly expressed in mononuclear cells (MNCs) from umbilical cord blood. Isoform 3 is highly expressed in lung, kidney, spleen and thymus. Down-regulated malignant tissue from different anatomical origins, including colon, breast, lung, stomach, cervix, and ovary.
Post Translational Modifications
Function Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site.
Protein Name Aryl Hydrocarbon Receptor Repressor
Ahr Repressor
Ahrr
Class E Basic Helix-Loop-Helix Protein 77
Bhlhe77
Database Links Reactome: R-HSA-1989781
Reactome: R-HSA-211945
Reactome: R-HSA-211976
Reactome: R-HSA-211981
Reactome: R-HSA-8937144
Cellular Localisation Cytoplasm
Nucleus
Predominantly In The Nuclear Compartment
First Cytoplasmic
Translocates Into The Nuclear Compartment Upon Interaction With Arnt In The Cytoplasmic Compartment
Alternative ELISA Names Aryl Hydrocarbon Receptor Repressor ELISA kit
Ahr Repressor ELISA kit
Ahrr ELISA kit
Class E Basic Helix-Loop-Helix Protein 77 ELISA kit
Bhlhe77 ELISA kit
AHRR ELISA kit
BHLHE77 ELISA kit
KIAA1234 ELISA kit
output

Information sourced from Uniprot.org

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