| Post Translational Modifications | The precursor is cleaved by a furin endopeptidase. Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion. |
| Function | Has anti-angiogenic properties. |
| Protein Name | A Disintegrin And Metalloproteinase With Thrombospondin Motifs 8Adam-Ts 8Adam-Ts8Adamts-8Meth-2Meth-8 |
| Database Links | Reactome: R-HSA-1474228Reactome: R-HSA-5083635Reactome: R-HSA-5173214 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Protein Names | A Disintegrin And Metalloproteinase With Thrombospondin Motifs 8 proteinAdam-Ts 8 proteinAdam-Ts8 proteinAdamts-8 proteinMeth-2 proteinMeth-8 proteinADAMTS8 proteinMETH2 protein |
Information sourced from Uniprot.org
