Human ACTG2 protein (Recombinant) (N-His) (STJP005050)

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STJP005050
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ACTG2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: ACTG2
Gene ID: 72
Uniprot ID: ACTH_HUMAN
Immunogen Region: Glu3-Phe376
Immunogen: Homo sapiens (Human)
Post Translational Modifications Oxidation of Met-45 and Met-48 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promotes actin repolymerization. Actin, gamma-enteric smooth muscle, intermediate form: N-terminal cleavage of acetylated cysteine of intermediate muscle actin by ACTMAP. Monomethylation at Lys-85 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. Methylated at His-74 by SETD3. (Microbial infection) Monomeric actin is cross-linked by V.cholerae toxins RtxA and VgrG1 in case of infection: bacterial toxins mediate the cross-link between Lys-51 of one monomer and Glu-271 of another actin monomer, resulting in formation of highly toxic actin oligomers that cause cell rounding. The toxin can be highly efficient at very low concentrations by acting on formin homology family proteins: toxic actin oligomers bind with high affinity to formins and adversely affect both nucleation and elongation abilities of formins, causing their potent inhibition in both profilin-dependent and independent manners.
Function Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Protein Name Actin - Gamma-Enteric Smooth Muscle
Alpha-Actin-3
Gamma-2-Actin
Smooth Muscle Gamma-Actin Cleaved Into - Actin - Gamma-Enteric Smooth Muscle - Intermediate Form
Database Links Reactome: R-HSA-445355
Cellular Localisation Cytoplasm
Cytoskeleton
Alternative Protein Names Actin - Gamma-Enteric Smooth Muscle protein
Alpha-Actin-3 protein
Gamma-2-Actin protein
Smooth Muscle Gamma-Actin Cleaved Into - Actin - Gamma-Enteric Smooth Muscle - Intermediate Form protein
ACTG2 protein
ACTA3 protein
ACTL3 protein
ACTSG protein

Information sourced from Uniprot.org

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