| Function | Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. It cleaves after Asp. Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore-forming moiety of GSDME, thereby triggering pyroptosis and target cell death. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -9 and -10 (CASP3, CASP9 and CASP10, respectively) to give rise to active enzymes mediating apoptosis. Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair. |
| Peptide Name | Granzyme BC11Ctla-1Cathepsin G-Like 1Ctsgl1Cytotoxic T-Lymphocyte Proteinase 2Lymphocyte ProteaseFragmentin-2Granzyme-2Human Lymphocyte ProteinHlpSectT-Cell Serine Protease 1-3e |
| Database Links | Reactome: R-HSA-2197563Reactome: R-HSA-5620971Reactome: R-HSA-75108Reactome: R-HSA-9725371 |
| Cellular Localisation | SecretedCytolytic GranuleDelivered Into The Target Cell By Perforin |
| Alternative Peptide Names | Granzyme B proteinC11 proteinCtla-1 proteinCathepsin G-Like 1 proteinCtsgl1 proteinCytotoxic T-Lymphocyte Proteinase 2 proteinLymphocyte Protease proteinFragmentin-2 proteinGranzyme-2 proteinHuman Lymphocyte Protein proteinHlp proteinSect proteinT-Cell Serine Protease 1-3e proteinGZMB proteinCGL1 proteinCSPB proteinCTLA1 proteinGRB protein |
Information sourced from Uniprot.org
