Trial size CBL antibodies available in the Antibody Validation Project

Posted by M.Popov on 12th Nov 2020

Trial size CBL antibodies available in the Antibody Validation Project

Trial size CBL antibodies available in the Antibody Validation Project

Introduction:

CBL is the gene encoding the Cbl proto-oncogene protein which is responsible for targeting substrates for proteasome degradation and mediating ubiquitin transport. Being an oncogene, it is found in mutated forms in many cancers, but specific mutations lead to chromosomal disorders and congenital genetic disorders. We provide a number of trial sized antibodies, which are suitable for CBL research purposes, and to help you make the right decision and find the best suited antibody for you, please find the answers to some of the key topics regarding CBL that we have provided in the links below.

What is CBL?

The CBL gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein, named Cbl proto-oncogene is one of the enzymes required for targeting substrates for degradation by the proteasome and it also mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. The Cbl proto-oncogene protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. 

Where is CBL found?

Inside the cell, CBL can be found mainly inside the cytosol and the protein has cytoplasmic expression in spermatogonia, subsets of immune cells and lymphoid tissues.

What role does CBL play in disease?

This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder. Apart from that, CBL is also linked with haematologic cancer, which is related to bone marrow cancer and mast cell neoplasm.

CBL antibodies in the Antibody Validation project

St John's Laboratory offers a variety of trial size primary antibodies which target CBL, which are available to try through the Antibody Validation Project. Below we highlight those which have already been reviewed, as well as others which are available to try.

Customer reviewed CBL antibodies

ModelNameHostClonalityRatingApplication Tested
STJ92057Anti-Cbl antibody RabbitPolyclonal4WB

Other CBL antibodies available in the Antibody Validation Project

ModelNameHostClonalityRecommended Applications
STJ90807Anti-Phospho-Cbl (Y674) antibodyRabbitPolyclonalWB,IHC,ELISA
STJ91035Anti-Phospho-Cbl (Y774) antibodyRabbitPolyclonalWB,IHC,IF,ELISA
STJ91036Anti-Phospho-Cbl (Y700) antibodyRabbitPolyclonalWB,IHC,IF,ELISA
STJ92055Anti-Cbl antibodyRabbitPolyclonalWB,IHC,IF,ELISA
STJ92056Anti-Cbl antibodyRabbitPolyclonalWB,IHC,IF,ELISA
STJ97898Anti-Cbl antibodyMouseMonoclonalWB,IHC,IF,FC,ELISA
ModelNameHostClonalityRecommended Applications
STJ110191Anti-CBL AntibodyRabbitPolyclonalWB,IHC
STJ116400Anti-Phospho-CBL-(Y700) AntibodyRabbitPolyclonalWB
STJ117892Anti-Phospho-CBL-(Y774) AntibodyRabbitPolyclonalWB
STJ22050Anti-Phospho-CBL-(Y700) AntibodyRabbitPolyclonalWB,IHC,IF
STJ22913Anti-CBL AntibodyRabbitPolyclonalWB,IHC
STJ70107Anti-CBL AntibodyGoatPolyclonalELISA,WB

How does the Antibody Validation Project work?

In order to help our customers with their choice of antibody with low risk, we offer one of the largest ranges of primary antibodies with trial size options available.

The Antibody Validation Project works like this.
1. Order your trial size antibody online.
2. Explore its suitability.
3. Return your results by posting them on the product page.
4. Receive a sample refund.

Find out more here.