| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | POLR1H |
| Gene ID: | 30834 |
| Uniprot ID: | RPA12_HUMAN |
| Immunogen Region: | 1-126 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-126 of human ZNRD1 (NP_055411.1). |
| Immunogen Sequence: | MSVMDLANTCSSFQSDLDFC SDCGSVLPLPGAQDTVTCIR CGFNINVRDFEGKVVKTSVV FHQLGTAMPMSVEEGPECQG PVVDRRCPRCGHEGMAYHTR QMRSADEGQTVFYTCTNCKF QEKEDS |
| Function | Core component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Can mediate Pol I proofreading of the nascent RNA transcript. Anchors into the Pol I active site to monitor transcription fidelity and cleave mis-incorporated 5'-ribonucleotides. |
| Protein Name | Dna-Directed Rna Polymerase I Subunit Rpa12Dna-Directed Rna Polymerase I Subunit HZinc Ribbon Domain-Containing Protein 1 |
| Database Links | Reactome: R-HSA-427413Reactome: R-HSA-5250924Reactome: R-HSA-73762Reactome: R-HSA-73772Reactome: R-HSA-73863 |
| Cellular Localisation | NucleusNucleolus |
| Alternative Antibody Names | Anti-Dna-Directed Rna Polymerase I Subunit Rpa12 antibodyAnti-Dna-Directed Rna Polymerase I Subunit H antibodyAnti-Zinc Ribbon Domain-Containing Protein 1 antibodyAnti-POLR1H antibodyAnti-RPA12 antibodyAnti-ZNRD1 antibody |
Information sourced from Uniprot.org