| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ZFYVE16 |
| Gene ID: | 9765 |
| Uniprot ID: | ZFY16_HUMAN |
| Immunogen Region: | 1-280 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human ZFYVE16 (NP_055548.3). |
| Immunogen Sequence: | MDSYFKAAVSDLDKLLDDFE QNPDEQDYLQDVQNAYDSNH CSVSSELASSQRTSLLPKDQ ECVNSCASSETSYGTNESSL NEKTLKGLTSIQNEKNVTGL DLLSSVDGGTSDEIQPLYMG RCSKPICDLISDMGNLVHAT NSEEDIKKLLPDDFKSNADS LIGLDLSSVSDTPCVSSTDH DSDTVREQQNDISSELQNRE IGGIKELGIKVDTTLSDSYN YSGTENLKDKKIFNQLESI |
| Tissue Specificity | Widely expressed. Highly expressed in kidney, placenta and lung. Expressed at intermediate level in heart, brain, skeletal muscle, spleen and liver. Weakly expressed in colon, thymus and peripheral blood lymphocytes. |
| Function | May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes. |
| Protein Name | Zinc Finger Fyve Domain-Containing Protein 16EndofinEndosome-Associated Fyve Domain Protein |
| Database Links | Reactome: R-HSA-201451 |
| Cellular Localisation | CytoplasmEarly Endosome MembranePeripheral Membrane ProteinLocalized To Early EndosomesMembrane-AssociatedProbably Via Its Association With Phosphatidylinositol 3-Phosphate (Pi3p) |
| Alternative Antibody Names | Anti-Zinc Finger Fyve Domain-Containing Protein 16 antibodyAnti-Endofin antibodyAnti-Endosome-Associated Fyve Domain Protein antibodyAnti-ZFYVE16 antibodyAnti-KIAA0305 antibody |
Information sourced from Uniprot.org