| Function | Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. Catalyzes palmitoylation of Cys residues in the cytoplasmic C-terminus of EGFR, and modulates the duration of EGFR signaling by modulating palmitoylation-dependent EGFR internalization and degradation. Has a preference for acyl-CoA with C16 fatty acid chains. Can also utilize acyl-CoA with C14 and C18 fatty acid chains. May palmitoylate CALHM1 subunit of gustatory voltage-gated ion channels and modulate channel gating and kinetics. (Microbial infection) Dominant palmitoyltransferase responsible for lipidation of SARS coronavirus-2/SARS-CoV-2 spike protein. Through a sequential action with ZDHHC9, rapidly and efficiently palmitoylates spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. |
| Protein Name | Palmitoyltransferase Zdhhc20Acyltransferase Zdhhc20Dhhc Domain-Containing Cysteine-Rich Protein 20Dhhc20Zinc Finger Dhhc Domain-Containing Protein 20 |
| Database Links | Reactome: R-HSA-9694548 |
| Cellular Localisation | Golgi Apparatus MembraneMulti-Pass Membrane ProteinCell MembraneCytoplasmPerinuclear RegionEndoplasmic Reticulum MembraneEndoplasmic Reticulum-Golgi Intermediate Compartment Membrane |
| Alternative Antibody Names | Anti-Palmitoyltransferase Zdhhc20 antibodyAnti-Acyltransferase Zdhhc20 antibodyAnti-Dhhc Domain-Containing Cysteine-Rich Protein 20 antibodyAnti-Dhhc20 antibodyAnti-Zinc Finger Dhhc Domain-Containing Protein 20 antibodyAnti-ZDHHC20 antibody |
Information sourced from Uniprot.org
