| Tissue Specificity | Expressed in oocytes and testicular germ cells in the stage of spermatogonia to spermatocyte. Also observed placental trophoblasts, as well as in vascular smooth muscle cells in the pulmonary artery, myocardium, and skeletal muscle. Undetectable in epithelial cells in respiratory, gastrointestinal, and urogenital tracts. Up-regulated in various carcinomas and germ cell tumors (at protein level). |
| Post Translational Modifications | Phosphorylated during oocyte maturation and dephosphorylated following egg activation. Phosphorylated in vitro by a kinase activity associated with testicular mRNPs. Dephosphorylation leads to a decrease in its affinity to bind RNA in vitro. |
| Function | Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full-length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5'-UCCAUCA-3' with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasmic storage, thereby linking transcription and mRNA storage/translational delay. |
| Protein Name | Y-Box-Binding Protein 2ContrinDna-Binding Protein CDbpcGerm Cell-Specific Y-Box-Binding ProteinMsy2 Homolog |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Y-Box-Binding Protein 2 antibodyAnti-Contrin antibodyAnti-Dna-Binding Protein C antibodyAnti-Dbpc antibodyAnti-Germ Cell-Specific Y-Box-Binding Protein antibodyAnti-Msy2 Homolog antibodyAnti-YBX2 antibodyAnti-CSDA3 antibodyAnti-MSY2 antibody |
Information sourced from Uniprot.org
