| Tissue Specificity | Expressed in the spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Isoform 2 is expressed predominantly in peripheral blood leukocytes. |
| Function | Possesses 5'->3' exoribonuclease activity. May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites. |
| Protein Name | 5'-3' Exoribonuclease 2Dhm1-Like ProteinDhp Protein |
| Database Links | Reactome: R-HSA-390471Reactome: R-HSA-6791226 |
| Cellular Localisation | NucleusNucleolus |
| Alternative Antibody Names | Anti-5'-3' Exoribonuclease 2 antibodyAnti-Dhm1-Like Protein antibodyAnti-Dhp Protein antibodyAnti-XRN2 antibody |
Information sourced from Uniprot.org
