| Host: |
Rabbit |
| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
VPS26B |
| Gene ID: |
112936 |
| Uniprot ID: |
VP26B_HUMAN |
| Immunogen Region: |
1-160 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human VPS26B (NP_443107.1). |
| Immunogen Sequence: |
MSFFGFGQSVEVEILLNDAE SRKRAEHKTEDGKKEKYFLF YDGETVSGKVSLALKNPNKR LEHQGIKIEFIGQIELYYDR GNHHEFVSLVKDLARPGEIT QSQAFDFEFTHVEKPYESYT GQNVKLRYFLRATISRRLND VVKEMDIVVHTLSTYPELNS |
| Function | Acts as a component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. May be involved in retrograde transport of SORT1 but not of IGF2R. Acts redundantly with VSP26A in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1. |
| Protein Name | Vacuolar Protein Sorting-Associated Protein 26bVesicle Protein Sorting 26b |
| Cellular Localisation | CytoplasmMembranePeripheral Membrane ProteinEarly EndosomeLate EndosomeLocalizes To Early And Late Endosomal Structures |
| Alternative Antibody Names | Anti-Vacuolar Protein Sorting-Associated Protein 26b antibodyAnti-Vesicle Protein Sorting 26b antibodyAnti-VPS26B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
