| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Vascular endothelial growth factor C (91-140 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IHC-P 1:100-1:300 ELISA 1:20000 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | VEGFC |
| Gene ID: | 7424 |
| Uniprot ID: | VEGFC_HUMAN |
| Immunogen Region: | 91-140 aa |
| Specificity: | VEGF-C Polyclonal Antibody detects endogenous levels of VEGF-C protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the Internal region of human VEGFC at the amino acid range 91-140 |
| Post Translational Modifications | Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3, but only the fully processed form could activate VEGFR-2. VEGF-C first form an antiparallel homodimer linked by disulfide bonds. Before secretion, a cleavage occurs between Arg-227 and Ser-228 producing a heterotetramer. The next extracellular step of the processing removes the N-terminal propeptide. Finally the mature VEGF-C is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions. |
| Function | Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors. |
| Protein Name | Vascular Endothelial Growth Factor C Vegf-C Flt4 Ligand Flt4-L Vascular Endothelial Growth Factor-Related Protein Vrp |
| Database Links | Reactome: R-HSA-114608 Reactome: R-HSA-194313 Reactome: R-HSA-195399 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Vascular Endothelial Growth Factor C antibody Anti-Vegf-C antibody Anti-Flt4 Ligand antibody Anti-Flt4-L antibody Anti-Vascular Endothelial Growth Factor-Related Protein antibody Anti-Vrp antibody Anti-VEGFC antibody |
Information sourced from Uniprot.org