| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
USP35 |
| Gene ID: |
57558 |
| Uniprot ID: |
UBP35_HUMAN |
| Immunogen Region: |
900 aa |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 900 to the C-terminus of human USP35 (NP_065849.1). |
| Immunogen Sequence: |
FSSFESVSNVTSFFPKDTAY VLFYRQRPREGPEAELGSSR VRTEPTLHKDLMEAISKDNI LYLQEQEKEARSRAAYISAL PTSPHWGRGFDEDKDEDEGS PGGCNPAGGNGGDFHRLVF |
| Tissue Specificity | Expressed in testis, pancreas and skeletal muscle. |
| Post Translational Modifications | Ubiquitinated by CHIP/STUB1 in an HSP90-dependent manner.leading to proteasomal degradation. This ubiquitination can be reversed through auto-deubiquitinating activity. |
| Function | Deubiquitinase that plays a role in different processes including cell cycle regulation, mitophagy or endoplasmic reticulum stress. Inhibits TNFalpha-induced NF-kappa-B activation through stabilizing TNIP2 protein via deubiquitination. Plays an essential role during mitosis by deubiquitinating and thereby regulating the levels of Aurora B/AURKB protein. In addition, regulates the protein levels of other key component of the chromosomal passenger complex (CPC) such as survivin/BIRC5 or Borealin/CDCA8 by enhancing their stability. Regulates the degradation of mitochondria through the process of autophagy termed mitophagy. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 35Deubiquitinating Enzyme 35Ubiquitin Thioesterase 35Ubiquitin-Specific-Processing Protease 35 |
| Cellular Localisation | CytoplasmMitochondrionOnly Associates With Polarized MitochondriaAnd Rapidly Translocates To The Cytosol During Mitophagy |
| Alternative Antibody Names | Anti-Ubiquitin Carboxyl-Terminal Hydrolase 35 antibodyAnti-Deubiquitinating Enzyme 35 antibodyAnti-Ubiquitin Thioesterase 35 antibodyAnti-Ubiquitin-Specific-Processing Protease 35 antibodyAnti-USP35 antibodyAnti-KIAA1372 antibodyAnti-USP34 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
