| Tissue Specificity | Expressed in testis, pancreas and skeletal muscle. |
| Post Translational Modifications | Ubiquitinated by CHIP/STUB1 in an HSP90-dependent manner.leading to proteasomal degradation. This ubiquitination can be reversed through auto-deubiquitinating activity. |
| Function | Deubiquitinase that plays a role in different processes including cell cycle regulation, mitophagy or endoplasmic reticulum stress. Inhibits TNFalpha-induced NF-kappa-B activation through stabilizing TNIP2 protein via deubiquitination. Plays an essential role during mitosis by deubiquitinating and thereby regulating the levels of Aurora B/AURKB protein. In addition, regulates the protein levels of other key component of the chromosomal passenger complex (CPC) such as survivin/BIRC5 or Borealin/CDCA8 by enhancing their stability. Regulates the degradation of mitochondria through the process of autophagy termed mitophagy. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 35Deubiquitinating Enzyme 35Ubiquitin Thioesterase 35Ubiquitin-Specific-Processing Protease 35 |
| Cellular Localisation | CytoplasmMitochondrionOnly Associates With Polarized MitochondriaAnd Rapidly Translocates To The Cytosol During Mitophagy |
| Alternative Antibody Names | Anti-Ubiquitin Carboxyl-Terminal Hydrolase 35 antibodyAnti-Deubiquitinating Enzyme 35 antibodyAnti-Ubiquitin Thioesterase 35 antibodyAnti-Ubiquitin-Specific-Processing Protease 35 antibodyAnti-USP35 antibodyAnti-KIAA1372 antibodyAnti-USP34 antibody |
Information sourced from Uniprot.org
