| Function | Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the small GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A, preventing CDC25A degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone deacetylation. Through activation of the Rho family GTPases RAC1A, CDC42 and RHOA, regulates cell migration. Through the cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains of the cytoplasmic innate immune receptors RIGI and IFIH1 stimulates the cellular response to viral infection. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 17Usp17Deubiquitinating Enzyme 17-Like Protein 2Deubiquitinating Protein 3Dub-3Ubiquitin Carboxyl-Terminal Hydrolase 17-Like Protein 2Ubiquitin Thioesterase 17-Like Protein 2Ubiquitin-Specific-Processing Protease 17-Like Protein 2 |
| Database Links | Reactome: R-HSA-5689880Reactome: R-HSA-9648002 |
| Cellular Localisation | NucleusEndoplasmic Reticulum |
| Alternative Antibody Names | Anti-Ubiquitin Carboxyl-Terminal Hydrolase 17 antibodyAnti-Usp17 antibodyAnti-Deubiquitinating Enzyme 17-Like Protein 2 antibodyAnti-Deubiquitinating Protein 3 antibodyAnti-Dub-3 antibodyAnti-Ubiquitin Carboxyl-Terminal Hydrolase 17-Like Protein 2 antibodyAnti-Ubiquitin Thioesterase 17-Like Protein 2 antibodyAnti-Ubiquitin-Specific-Processing Protease 17-Like Protein 2 antibodyAnti-USP17L2 antibodyAnti-DUB3 antibodyAnti-USP17 antibodyAnti-USP17H antibodyAnti-USP17I antibodyAnti-USP17J antibodyAnti-USP17K antibodyAnti-USP17L antibodyAnti-USP17M antibody |
Information sourced from Uniprot.org
