| Function | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation.the function is independent of association with UPF2 and components of the EJC core. |
| Protein Name | Regulator Of Nonsense Transcripts 3bNonsense Mrna Reducing Factor 3bUp-Frameshift Suppressor 3 Homolog BHupf3bUp-Frameshift Suppressor 3 Homolog On Chromosome XHupf3p-X |
| Database Links | Reactome: R-HSA-159236Reactome: R-HSA-72163Reactome: R-HSA-72187Reactome: R-HSA-73856Reactome: R-HSA-9010553Reactome: R-HSA-975957 |
| Cellular Localisation | NucleusCytoplasmShuttling Between The Nucleus And The Cytoplasm |
| Alternative Antibody Names | Anti-Regulator Of Nonsense Transcripts 3b antibodyAnti-Nonsense Mrna Reducing Factor 3b antibodyAnti-Up-Frameshift Suppressor 3 Homolog B antibodyAnti-Hupf3b antibodyAnti-Up-Frameshift Suppressor 3 Homolog On Chromosome X antibodyAnti-Hupf3p-X antibodyAnti-UPF3B antibodyAnti-RENT3B antibodyAnti-UPF3X antibody |
Information sourced from Uniprot.org
