| Function | Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform present at high concentrations in the brain, kidney and pancreas, and is required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione.K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzyme: coenzyme Q10, also named ubiquinone, plays an important antioxidant role in the cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress. |
| Protein Name | Ubia Prenyltransferase Domain-Containing Protein 1Transitional Epithelial Response Protein 1 |
| Database Links | Reactome: R-HSA-6806664 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinGolgi Apparatus MembraneMitochondrion MembraneCytoplasmNucleus |
| Alternative Antibody Names | Anti-Ubia Prenyltransferase Domain-Containing Protein 1 antibodyAnti-Transitional Epithelial Response Protein 1 antibodyAnti-UBIAD1 antibodyAnti-TERE1 antibody |
Information sourced from Uniprot.org
