| Tissue Specificity | In the embryo, highly expressed in chondrogenic cells. In embryonic skin, expressed in the undifferentiated mesenchymal layer beneath the epidermis which later develops into the dermis. Expressed in early myeloid cells but not in lymphoid cells in the liver. Expression also detected in the secretory ependymal epithelium of the choroid plexus primordium. In the adult, expressed in secreting glandular tissues and tubules. |
| Function | Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of pro-inflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism. Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors. |
| Protein Name | Twist-Related Protein 2Class A Basic Helix-Loop-Helix Protein 39Bhlha39Dermis-Expressed Protein 1Dermo-1 |
| Database Links | Reactome: R-HSA-8878166 |
| Cellular Localisation | NucleusCytoplasmMainly Nuclear During Embryonic DevelopmentCytoplasmic In Adult Tissues |
| Alternative Antibody Names | Anti-Twist-Related Protein 2 antibodyAnti-Class A Basic Helix-Loop-Helix Protein 39 antibodyAnti-Bhlha39 antibodyAnti-Dermis-Expressed Protein 1 antibodyAnti-Dermo-1 antibodyAnti-TWIST2 antibodyAnti-BHLHA39 antibodyAnti-DERMO1 antibody |
Information sourced from Uniprot.org
