| Function | Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight. Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages. |
| Protein Name | Tubby Protein Homolog |
| Cellular Localisation | CytoplasmNucleusSecretedCell MembranePeripheral Membrane ProteinCytoplasmic SideBinds Phospholipid And Is Anchored To The Plasma Membrane Through Binding Phosphatidylinositol 45-BisphosphateIs Released Upon Activation Of Phospholipase CTranslocates From The Plasma Membrane To The Nucleus Upon Activation Of Guanine Nucleotide-Binding Protein G(Q) Subunit AlphaDoes Not Have A Cleavable Signal Peptide And Is Secreted By A Non-Conventional Pathway |
| Alternative Antibody Names | Anti-Tubby Protein Homolog antibodyAnti-TUB antibody |
Information sourced from Uniprot.org
