| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Protein tweety homolog 2 (319-369 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TTYH2 |
| Gene ID: | 94015 |
| Uniprot ID: | TTYH2_HUMAN |
| Immunogen Region: | 319-369 aa |
| Specificity: | This antibody detects endogenous levels of TTYH2 at Human/Mouse |
| Immunogen: | Synthesized peptide derived from the human TTYH2 at the amino acid range 319-369 |
| Post Translational Modifications | N- Glycosylated. Contains high-mannose, hybrid and complex oligosaccharides. Ubiquitinated by NEDD4L, leading to its proteasomal degradation. |
| Function | Calcium-independent, swelling-dependent volume-regulated anion channel (VRAC-swell) which plays a pivotal role in the process of regulatory volume decrease (RVD) in the brain through the efflux of anions like chloride and organic osmolytes like glutamate. Probable large-conductance Ca(2+)-activated chloride channel. |
| Protein Name | Protein Tweety Homolog 2Htty2Volume-Regulated Anion Channel Subunit Ttyh2 |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Protein Tweety Homolog 2 antibodyAnti-Htty2 antibodyAnti-Volume-Regulated Anion Channel Subunit Ttyh2 antibodyAnti-TTYH2 antibodyAnti-C17orf29 antibody |
Information sourced from Uniprot.org