| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
TTLL7 |
| Gene ID: |
79739 |
| Uniprot ID: |
TTLL7_HUMAN |
| Immunogen Region: |
1-260 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human TTLL7 (NP_078962.4). |
| Immunogen Sequence: |
MPSLPQEGVIQGPSPLDLNT ELPYQSTMKRKVRKKKKKGT ITANVAGTKFEIVRLVIDEM GFMKTPDEDETSNLIWCDSA VQQEKISELQNYQRINHFPG MGEICRKDFLARNMTKMIKS RPLDYTFVPRTWIFPAEYTQ FQNYVKELKKKRKQKTFIVK PANGAMGHGISLIRNGDKLP SQDHLIVQEYIEKPFLMEGY KFDLRIYILVTSCDPLKIFL YHDGLVRMGTEKYIPPNES |
| Tissue Specificity | Highly expressed in the nervous system including spinal cord, thalamus, hippocampus, hypothalamus and cerebellum. |
| Function | Polyglutamylase which modifies tubulin, generating polyglutamate side chains of variable lengths on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin. Mediates both ATP-dependent initiation and elongation steps of the polyglutamylation reaction. Preferentially modifies the beta-tubulin tail over an alpha-tail. Competes with monoglycylase TTLL3 for modification site on beta-tubulin substrate, thereby creating an anticorrelation between glycylation and glutamylation reactions. Required for neurite growth.responsible for the strong increase in tubulin polyglutamylation during postnatal neuronal maturation. |
| Protein Name | Tubulin Polyglutamylase Ttll7Testis Development Protein Nyd-Sp30Tubulin--Tyrosine Ligase-Like Protein 7 |
| Database Links | Reactome: R-HSA-8955332 |
| Cellular Localisation | Cell ProjectionCiliumCytoplasmCytoskeletonCilium Basal BodyDendritePerikaryonIn Cells With Primary CiliaFound In Both Cilia And Basal BodiesIn Neuronal CellsFound In Dendrites And Perikaryon |
| Alternative Antibody Names | Anti-Tubulin Polyglutamylase Ttll7 antibodyAnti-Testis Development Protein Nyd-Sp30 antibodyAnti-Tubulin--Tyrosine Ligase-Like Protein 7 antibodyAnti-TTLL7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
