| Tissue Specificity | Highly expressed in the nervous system including spinal cord, thalamus, hippocampus, hypothalamus and cerebellum. |
| Function | Polyglutamylase which modifies tubulin, generating polyglutamate side chains of variable lengths on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin. Mediates both ATP-dependent initiation and elongation steps of the polyglutamylation reaction. Preferentially modifies the beta-tubulin tail over an alpha-tail. Competes with monoglycylase TTLL3 for modification site on beta-tubulin substrate, thereby creating an anticorrelation between glycylation and glutamylation reactions. Required for neurite growth.responsible for the strong increase in tubulin polyglutamylation during postnatal neuronal maturation. |
| Protein Name | Tubulin Polyglutamylase Ttll7Testis Development Protein Nyd-Sp30Tubulin--Tyrosine Ligase-Like Protein 7 |
| Database Links | Reactome: R-HSA-8955332 |
| Cellular Localisation | Cell ProjectionCiliumCytoplasmCytoskeletonCilium Basal BodyDendritePerikaryonIn Cells With Primary CiliaFound In Both Cilia And Basal BodiesIn Neuronal CellsFound In Dendrites And Perikaryon |
| Alternative Antibody Names | Anti-Tubulin Polyglutamylase Ttll7 antibodyAnti-Testis Development Protein Nyd-Sp30 antibodyAnti-Tubulin--Tyrosine Ligase-Like Protein 7 antibodyAnti-TTLL7 antibody |
Information sourced from Uniprot.org
