| Tissue Specificity | Strongly expressed in placenta. Expressed at lower levels in heart, pancreas, kidney and brain. Expressed in endothelial cells. Isoform alpha was found to be the predominant isoform. Isoform beta was not found in pancreas and brain. |
| Post Translational Modifications | Phosphorylation modulates TRPC channel function by regulating the level of TRPC4 at the cell surface and by increasing the association with NHERF1. |
| Function | Forms a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Forms a homomeric ion channel or a heteromeric ion channel with TRPC1.the heteromeric ion channel has reduced calcium permeability compared to the homomeric channel. Also permeable to monovalent ions including sodium, lithium and cesium ions. Isoform Beta: Forms a receptor-activated non-selective calcium permeant cation channel. |
| Protein Name | Short Transient Receptor Potential Channel 4Trpc4Trp-Related Protein 4Htrp-4Htrp4 |
| Database Links | Reactome: R-HSA-3295583Reactome: R-HSA-418890 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEnhanced Insertion Into The Cell Membrane After Activation Of The Egf ReceptorIsoform Beta: Cell Membrane |
| Alternative Antibody Names | Anti-Short Transient Receptor Potential Channel 4 antibodyAnti-Trpc4 antibodyAnti-Trp-Related Protein 4 antibodyAnti-Htrp-4 antibodyAnti-Htrp4 antibodyAnti-TRPC4 antibody |
Information sourced from Uniprot.org
