| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TRPC4 (768-977) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TRPC4 |
| Gene ID: |
7223 |
| Uniprot ID: |
TRPC4_HUMAN |
| Immunogen Region: |
768-977 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 768-977 of human TRPC4 (NP_057263.1). |
| Immunogen Sequence: |
SKESSNSADSDEKSDSEGNS KDKKKNFSLFDLTTLIHPRS AAIASERHNISNGSALVVQE PPREKQRKVNFVTDIKNFGL FHRRSKQNAAEQNANQIFSV SEEVARQQAAGPLERNIQLE SRGLASRGDLSIPGLSEQCV LVDHRERNTDTLGLQVGKRV CPFKSEKVVVEDTVPIIPKE KHAKEEDSSIDYDLNLPDTV THEDYVTTRL |
| Tissue Specificity | Strongly expressed in placenta. Expressed at lower levels in heart, pancreas, kidney and brain. Expressed in endothelial cells. Isoform alpha was found to be the predominant isoform. Isoform beta was not found in pancreas and brain. |
| Post Translational Modifications | Phosphorylation modulates TRPC channel function by regulating the level of TRPC4 at the cell surface and by increasing the association with NHERF1. |
| Function | Forms a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion. |
| Protein Name | Short Transient Receptor Potential Channel 4Trpc4Trp-Related Protein 4Htrp-4Htrp4 |
| Database Links | Reactome: R-HSA-3295583Reactome: R-HSA-418890 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinCell MembraneEnhanced Insertion Into The Cell Membrane After Activation Of The Egf Receptor |
| Alternative Antibody Names | Anti-Short Transient Receptor Potential Channel 4 antibodyAnti-Trpc4 antibodyAnti-Trp-Related Protein 4 antibodyAnti-Htrp-4 antibodyAnti-Htrp4 antibodyAnti-TRPC4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
