Anti-TriMethyl-Histone H1.4-K26 antibody (STJ11106421)

SKU:
STJ11106421
£129.50 - £642.50
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Host: Rabbit
Applications: IF/ICC/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: IF/ICC:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Gene Symbol: H1-4
Gene ID: 3008
Uniprot ID: H14_HUMAN
Specificity: A synthetic trimethylated peptide around K26 of human Histone H14 (NP_005312.1).
Immunogen Sequence: ARKSA
Post Translational Modifications H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter. Acetylated at Lys-26. Deacetylated at Lys-26 by SIRT1. Citrullination at Arg-54 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. ADP-ribosylated on Ser-150 in response to DNA damage.
Function Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation.
Protein Name Histone H1.4
Histone H1b
Histone H1s-4
Database Links Reactome: R-HSA-140342
Reactome: R-HSA-2559584
Cellular Localisation Nucleus
Chromosome
Mainly Localizes In Heterochromatin
Dysplays A Punctuate Staining Pattern In The Nucleus
Alternative Antibody Names Anti-Histone H1.4 antibody
Anti-Histone H1b antibody
Anti-Histone H1s-4 antibody
Anti-H1-4 antibody
Anti-H1F4 antibody
Anti-HIST1H1E antibody

Information sourced from Uniprot.org

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