| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Tripartite motif-containing protein 55 (75-125) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:1000-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TRIM55 |
| Gene ID: |
84675 |
| Uniprot ID: |
TRI55_HUMAN |
| Immunogen Region: |
75-125 |
| Specificity: |
This antibody detects endogenous levels of human TRI55 |
| Immunogen: |
Synthesized peptide derived from human TRI55 AA range: 75-125 |
| Post Translational Modifications | Targeted for degradation through the proteasomal and lysosomal pathways in the presence of SUMO3. |
| Function | E3 ubiquitin ligase that plays an important role in regulating cardiac development and contractility, muscle growth, metabolism, and fiber-type differentiation. Acts as a critical factor that regulates cardiomyocyte size during development in concert with TRIM63 by regulating E2F1-mediated gene expression. Plays a role in apoptosis induction in cardiomyocytes by promoting ubiquitination of the DUSP1 phosphatase. Promotes non-canonical NF-kappa-B signaling and B-cell-mediated immune responses by mediating NFKB2 'Lys-48'-linked ubiquitination and processing. In turn, NFKB2 is further processed by valosin-containing protein/VCP, an ATPase that mediates ubiquitin-dependent protein degradation by the proteasome. May play a role in preventing macrophages from producing inflammatory factors and migrating by downregulating the level of nuclear NF-kappa-B subunit RELA. Modifies also PPARG via polyubiquitination and accelerates PPARG proteasomal degradation to inhibit its activity. |
| Protein Name | Tripartite Motif-Containing Protein 55Muscle-Specific Ring Finger Protein 2Murf-2Murf2Ring Finger Protein 29 |
| Cellular Localisation | NucleusCytoplasmTlr4 Signaling Pathway Promotes Nuclear Translocation |
| Alternative Antibody Names | Anti-Tripartite Motif-Containing Protein 55 antibodyAnti-Muscle-Specific Ring Finger Protein 2 antibodyAnti-Murf-2 antibodyAnti-Murf2 antibodyAnti-Ring Finger Protein 29 antibodyAnti-TRIM55 antibodyAnti-MURF2 antibodyAnti-RNF29 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
