| Post Translational Modifications | Targeted for degradation through the proteasomal and lysosomal pathways in the presence of SUMO3. |
| Function | E3 ubiquitin ligase that plays an important role in regulating cardiac development and contractility, muscle growth, metabolism, and fiber-type differentiation. Acts as a critical factor that regulates cardiomyocyte size during development in concert with TRIM63 by regulating E2F1-mediated gene expression. Plays a role in apoptosis induction in cardiomyocytes by promoting ubiquitination of the DUSP1 phosphatase. Promotes non-canonical NF-kappa-B signaling and B-cell-mediated immune responses by mediating NFKB2 'Lys-48'-linked ubiquitination and processing. In turn, NFKB2 is further processed by valosin-containing protein/VCP, an ATPase that mediates ubiquitin-dependent protein degradation by the proteasome. May play a role in preventing macrophages from producing inflammatory factors and migrating by downregulating the level of nuclear NF-kappa-B subunit RELA. Modifies also PPARG via polyubiquitination and accelerates PPARG proteasomal degradation to inhibit its activity. |
| Protein Name | Tripartite Motif-Containing Protein 55Muscle-Specific Ring Finger Protein 2Murf-2Murf2Ring Finger Protein 29 |
| Cellular Localisation | NucleusCytoplasmTlr4 Signaling Pathway Promotes Nuclear Translocation |
| Alternative Antibody Names | Anti-Tripartite Motif-Containing Protein 55 antibodyAnti-Muscle-Specific Ring Finger Protein 2 antibodyAnti-Murf-2 antibodyAnti-Murf2 antibodyAnti-Ring Finger Protein 29 antibodyAnti-TRIM55 antibodyAnti-MURF2 antibodyAnti-RNF29 antibody |
Information sourced from Uniprot.org
