| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Tripartite motif-containing protein 55 (75-125) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:1000-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TRIM55 |
| Gene ID: | 84675 |
| Uniprot ID: | TRI55_HUMAN |
| Immunogen Region: | 75-125 |
| Specificity: | This antibody detects endogenous levels of human TRI55 |
| Immunogen: | Synthesized peptide derived from human TRI55 AA range: 75-125 |
| Post Translational Modifications | Targeted for degradation through the proteasomal and lysosomal pathways in the presence of SUMO3. |
| Function | E3 ubiquitin ligase that plays an important role in regulating cardiac development and contractility, muscle growth, metabolism, and fiber-type differentiation. Acts as a critical factor that regulates cardiomyocyte size during development in concert with TRIM63 by regulating E2F1-mediated gene expression. Plays a role in apoptosis induction in cardiomyocytes by promoting ubiquitination of the DUSP1 phosphatase. Promotes non-canonical NF-kappa-B signaling and B-cell-mediated immune responses by mediating NFKB2 'Lys-48'-linked ubiquitination and processing. In turn, NFKB2 is further processed by valosin-containing protein/VCP, an ATPase that mediates ubiquitin-dependent protein degradation by the proteasome. May play a role in preventing macrophages from producing inflammatory factors and migrating by downregulating the level of nuclear NF-kappa-B subunit RELA. Modifies also PPARG via polyubiquitination and accelerates PPARG proteasomal degradation to inhibit its activity. |
| Protein Name | Tripartite Motif-Containing Protein 55 Muscle-Specific Ring Finger Protein 2 Murf-2 Murf2 Ring Finger Protein 29 |
| Cellular Localisation | Nucleus Cytoplasm Tlr4 Signaling Pathway Promotes Nuclear Translocation |
| Alternative Antibody Names | Anti-Tripartite Motif-Containing Protein 55 antibody Anti-Muscle-Specific Ring Finger Protein 2 antibody Anti-Murf-2 antibody Anti-Murf2 antibody Anti-Ring Finger Protein 29 antibody Anti-TRIM55 antibody Anti-MURF2 antibody Anti-RNF29 antibody |
Information sourced from Uniprot.org