| Tissue Specificity | High expression in spinal cord and moderate expression in all other tissues and specific brain regions examined. Expressed in all cell lines examined. |
| Post Translational Modifications | O-glycosylated. Glycosylated by OGT.glycosylation in response to increased extracellular glucose levels is required for and leads to regulation of mitochondrial motility by OGT. |
| Function | Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors. Involved in mitochondrial motility. When O-glycosylated, abolishes mitochondrial motility. Crucial for recruiting OGT to the mitochondrial surface of neuronal processes. TRAK1 and RHOT form an essential protein complex that links KIF5 to mitochondria for light chain-independent, anterograde transport of mitochondria. |
| Protein Name | Trafficking Kinesin-Binding Protein 1106 Kda O-Glcnac Transferase-Interacting ProteinProtein Milton |
| Database Links | Reactome: R-HSA-6802952Reactome: R-HSA-9013419Reactome: R-HSA-9013425 |
| Cellular Localisation | CytoplasmNucleusMitochondrionEarly EndosomeEndosomeMitochondrion MembraneCell CortexPredominantly Associated With Early EndosomeThe Localization To Early Endosomes Depends On Its Interaction With Hgs/HrsColocalizes With Mgarp At The Mitochondria |
| Alternative Antibody Names | Anti-Trafficking Kinesin-Binding Protein 1 antibodyAnti-106 Kda O-Glcnac Transferase-Interacting Protein antibodyAnti-Protein Milton antibodyAnti-TRAK1 antibodyAnti-KIAA1042 antibodyAnti-OIP106 antibody |
Information sourced from Uniprot.org
