| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TRAF5 |
| Gene ID: | 7188 |
| Uniprot ID: | TRAF5_HUMAN |
| Immunogen Region: | 1-80 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human TRAF5 (NP_665702.1). |
| Immunogen Sequence: | MAYSEEHKGMPCGFIRQNSG NSISLDFEPSIEYQFVERLE ERYKCAFCHSVLHNPHQTGC GHRFCQHCILSLRELNTVPI |
| Tissue Specificity | Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, and peripheral blood. |
| Post Translational Modifications | Ubiquitinated at Lys-318 by the SCF(FBXL2) complex, leading to its degradation by the proteasome. |
| Function | Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. |
| Protein Name | Tnf Receptor-Associated Factor 5Ring Finger Protein 84 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Tnf Receptor-Associated Factor 5 antibodyAnti-Ring Finger Protein 84 antibodyAnti-TRAF5 antibodyAnti-RNF84 antibody |
Information sourced from Uniprot.org