| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TPM4 (1-248) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TPM4 |
| Gene ID: |
7171 |
| Uniprot ID: |
TPM4_HUMAN |
| Immunogen Region: |
1-248 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-248 of human TPM4 (NP_003281.1). |
| Immunogen Sequence: |
MAGLNSLEAVKRKIQALQQQ ADEAEDRAQGLQRELDGERE RREKAEGDVAALNRRIQLVE EELDRAQERLATALQKLEEA EKAADESERGMKVIENRAMK DEEKMEIQEMQLKEAKHIAE EADRKYEEVARKLVILEGEL ERAEERAEVSELKCGDLEEE LKNVTNNLKSLEAASEKYSE KEDKYEEEIKLLSDKLKEAE TRAEFAERTVAKLEKTIDDL EEKLAQAKEENVGLHQTLD |
| Tissue Specificity | Detected in cardiac tissue and platelets, the form found in cardiac tissue is a higher molecular weight than the form found in platelets. Expressed at higher levels in the platelets of hypertensive patients with cardiac hypertrophy than in the platelets of hypertensive patients without cardiac hypertrophy (at protein level). |
| Function | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium. |
| Protein Name | Tropomyosin Alpha-4 ChainTm30p1Tropomyosin-4 |
| Database Links | Reactome: R-HSA-390522Reactome: R-HSA-445355Reactome: R-HSA-9013424Reactome: R-HSA-9725370 |
| Cellular Localisation | CytoplasmCytoskeletonAssociates With F-Actin Stress Fibers |
| Alternative Antibody Names | Anti-Tropomyosin Alpha-4 Chain antibodyAnti-Tm30p1 antibodyAnti-Tropomyosin-4 antibodyAnti-TPM4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
