• Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using TNF Receptor I Antibody. The picture on the right is blocked with the synthesized peptide.
  • Immunohistochemical analysis of paraffin-embedded Human kidney. 1, Antibody was diluted at 1:200 (4°C overnight). 2, High-pressure and temperature EDTA, pH8.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 30min).
  • Immunohistochemical analysis of paraffin-embedded Human kidney. 1, Antibody was diluted at 1:200 (4°C overnight). 2, High-pressure and temperature EDTA, pH8.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 30min).
  • Immunohistochemical analysis of paraffin-embedded Human kidney. 1, Antibody was diluted at 1:200 (4°C overnight). 2, High-pressure and temperature EDTA, pH8.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 30min).

Anti-TNFRSF1A antibody (381-430 aa) (STJ96052)

SKU:
STJ96052

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: IHC/IF/WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Tumor necrosis factor receptor superfamily member 1A (381-430 aa) is suitable for use in Immunohistochemistry, Immunofluorescence, Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
IHC 1:100-1:300
ELISA 1:20000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TNFRSF1A
Gene ID: 7132
Uniprot ID: TNR1A_HUMAN
Immunogen Region: 381-430 aa
Specificity: TNF-R1 Polyclonal Antibody detects endogenous levels of TNF-R1 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human TNF Receptor I at the amino acid range 381-430
Function Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
Protein Name Tumor Necrosis Factor Receptor Superfamily Member 1a
Tumor Necrosis Factor Receptor 1
Tnf-R1
Tumor Necrosis Factor Receptor Type I
Tnf-Ri
Tnfr-I
P55
P60
Cd Antigen Cd120a Cleaved Into - Tumor Necrosis Factor Receptor Superfamily Member 1a - Membrane Form - Tumor Necrosis Factor-Binding Protein 1
Tbpi
Database Links Reactome: R-HSA-5357786
Reactome: R-HSA-5357905
Reactome: R-HSA-5357956
Reactome: R-HSA-5626978
Reactome: R-HSA-5669034
Reactome: R-HSA-6783783
Reactome: R-HSA-75893
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Golgi Apparatus Membrane
Secreted
A Secreted Form Is Produced Through Proteolytic Processing
Isoform 4: Secreted
Lacks A Golgi-Retention Motif
Is Not Membrane Bound And Therefore Is Secreted
Alternative Antibody Names Anti-Tumor Necrosis Factor Receptor Superfamily Member 1a antibody
Anti-Tumor Necrosis Factor Receptor 1 antibody
Anti-Tnf-R1 antibody
Anti-Tumor Necrosis Factor Receptor Type I antibody
Anti-Tnf-Ri antibody
Anti-Tnfr-I antibody
Anti-P55 antibody
Anti-P60 antibody
Anti-Cd Antigen Cd120a Cleaved Into - Tumor Necrosis Factor Receptor Superfamily Member 1a - Membrane Form - Tumor Necrosis Factor-Binding Protein 1 antibody
Anti-Tbpi antibody
Anti-TNFRSF1A antibody
Anti-TNFAR antibody
Anti-TNFR1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance