| Post Translational Modifications | N-glycosylated. |
| Function | Transmembrane protein that binds to and facilitates the assembly of lysosomal proton-transporting V-type ATPase (v-ATPase), resulting in enhanced lysosomal acidification and trafficking. By bringing the v-ATPase accessory protein ATP6AP2 and the v-ATPase subunit ATP6V0D1 together, allows v-ATPase complex formation and activation. TMEM9-controlled vesicular acidification induces hyperactivation of Wnt/beta-catenin signaling, involved in development, tissue homeostasis and tissue regeneration, through lysosomal degradation of adenomatous polyposis coli/APC. In the liver, involved in hepatic regeneration. |
| Protein Name | Proton-Transporting V-Type Atpase Complex Assembly Regulator Tmem9V-Atpase Assembly Regulator Tmem9Dermal Papilla-Derived Protein 4Transmembrane Protein 9Protein Tmem9 |
| Database Links | |
| Cellular Localisation | Lysosome MembraneSingle-Pass Type I Membrane ProteinLate Endosome MembraneEndosomeMultivesicular Body Membrane |
| Alternative Antibody Names | Anti-Proton-Transporting V-Type Atpase Complex Assembly Regulator Tmem9 antibodyAnti-V-Atpase Assembly Regulator Tmem9 antibodyAnti-Dermal Papilla-Derived Protein 4 antibodyAnti-Transmembrane Protein 9 antibodyAnti-Protein Tmem9 antibodyAnti-TMEM9 antibodyAnti-DERP4 antibodyAnti-TMEM9A antibodyAnti-HSPC186 antibodyAnti-PSEC0012 antibodyAnti-UNQ631 antibodyAnti-PRO1248 antibody |
Information sourced from Uniprot.org
