| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TMEM100 (C-Term) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TMEM100 |
| Gene ID: |
55273 |
| Uniprot ID: |
TM100_HUMAN |
| Immunogen Region: |
C-Term |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 50 to the C-terminus of human TMEM100 (NP_001093110.1). |
| Immunogen Sequence: |
ELSCYRCIIPFAVVVFIAGI VVTAVAYSFNSHGSIISIFG LVVLSSGLFLLASSALCWKV RQRSKKAKRRESQTALVANQ RSLFA |
| Tissue Specificity | Expressed in neurons of the myenteric and submucosal plexuses in the gastric body, jejunum and proximal colon. Expressed in arterial endothelial cells and neurons of the central nervous system and peripheral nervous system. Expressed in umbilical artery endothelial cells (at protein level). |
| Function | Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex. |
| Protein Name | Transmembrane Protein 100 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinMembranePerikaryonCytoplasmPerinuclear RegionEndoplasmic ReticulumColocalized With Hspa5 In The Endoplasmic Reticulum (Er)Enriched In Er MicrosomeColocalized With Bmp4 In Neural Cell Bodies And Neural Fibers Of The Enteric Nervous System |
| Alternative Antibody Names | Anti-Transmembrane Protein 100 antibodyAnti-TMEM100 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
