| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | TLE3 |
| Gene ID: | 7090 |
| Uniprot ID: | TLE3_HUMAN |
| Immunogen Region: | 158-240 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 158-240 of human TLE3 (NP_005069.2). |
| Immunogen Sequence: | PVTGSSSGLLALGALGSQAH LTVKDEKNHHELDHRERESS ANNSVSPSESLRASEKHRGS ADYSMEAKKRKAEEKDSLSR YDS |
| Tissue Specificity | Placenta and lung. |
| Post Translational Modifications | Ubiquitinated by XIAP/BIRC4. This ubiquitination does not affect its stability, nuclear localization, or capacity to tetramerize but inhibits its interaction with TCF7L2/TCF4. Ubiquitinated at Lys-720 by UBR5 in response to Wnt signaling, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome. |
| Function | Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. |
| Protein Name | Transducin-Like Enhancer Protein 3Enhancer Of Split Groucho-Like Protein 3Esg3 |
| Database Links | Reactome: R-HSA-201722Reactome: R-HSA-2122947 Q04726-3Reactome: R-HSA-3769402Reactome: R-HSA-4641265Reactome: R-HSA-9018519 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transducin-Like Enhancer Protein 3 antibodyAnti-Enhancer Of Split Groucho-Like Protein 3 antibodyAnti-Esg3 antibodyAnti-TLE3 antibodyAnti-KIAA1547 antibody |
Information sourced from Uniprot.org