| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | THAP1 |
| Gene ID: | 55145 |
| Uniprot ID: | THAP1_HUMAN |
| Immunogen Region: | 1-213 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-213 of human THAP1 (NP_060575.1). |
| Immunogen Sequence: | MVQSCSAYGCKNRYDKDKPV SFHKFPLTRPSLCKEWEAAV RRKNFKPTKYSSICSEHFTP DCFKRECNNKLLKENAVPTI FLCTEPHDKKEDLLEPQEQL PPPPLPPPVSQVDAAIGLLM PPLQTPVNLSVFCDHNYTVE DTMHQRKRIHQLEQQVEKLR KKLKTAQQRCRRQERQLEKL KEVVHFQKEKDDVSERGYVI LPNDYFEIVEVPA |
| Tissue Specificity | Highly expressed in heart, skeletal muscle, kidney and liver. Weaker expression in brain and placenta. |
| Function | DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-ATNTNNGTGGCAAGT-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptotic activity by potentiating both serum-withdrawal and TNF-induced apoptosis. |
| Protein Name | Thap Domain-Containing Protein 1 |
| Cellular Localisation | NucleusNucleoplasmPml Body |
| Alternative Antibody Names | Anti-Thap Domain-Containing Protein 1 antibodyAnti-THAP1 antibody |
Information sourced from Uniprot.org