| Post Translational Modifications | N- and O-glycosylated. May be proteolytically processed during the epididymal transit of spermatozoa. Ubiquitinated, leading to its degradation. Deubiquitinated by USP16, promoting its stability. |
| Function | Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility. |
| Protein Name | Tektin-3 |
| Cellular Localisation | CytoplasmCytoskeletonCilium AxonemeFlagellum AxonemeCytoplasmic VesicleSecretory VesicleAcrosome Outer MembranePeripheral Membrane ProteinIn SpermatozoaPreferentially Localizes To The FlagellaBut Also Found In The HeadIn The Sperm FlagellumLocalizes To The Periaxonemal Region Where It Associates With The Mitochondrial Sheath And Outer Dense FibersNot Detected In The Central Axonemal Region Of The FlagellumAssociates With The Acrosome Membrane In The Equatorial Segment Of The Sperm HeadAlso Detected Just Below The Plasma Membrane In The Post-Acrosomal Region Where It Might Localize To The Postacrosomal Dense LaminaHoweverOther Studies Report Little Or No Expression In The Postacrosomal RegionTranslocates From The Postacrosomal Region To The Equatorial Segment After Sperm ActivationRetained In The Postacromal RegionBut Not The Equatorial SegmentFollowing The Acrosome ReactionSome Studies Report Strong Expression In The Anterior Cap RegionOther Studies Report Little Or No Expression In The Acrosomal Cap |
| Alternative Antibody Names | Anti-Tektin-3 antibodyAnti-TEKT3 antibody |
Information sourced from Uniprot.org
