| Function | Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth. The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling. The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1. |
| Protein Name | Tbc1 Domain Family Member 7Cell Migration-Inducing Protein 23 |
| Database Links | Reactome: R-HSA-8854214 |
| Cellular Localisation | Lysosome MembraneCytoplasmic VesicleCytoplasmCytosolLocalizes In The Cytoplasmic Vesicles Of The Endomembrane In Association With The Tsc-Tbc ComplexRecruited To Lysosomal Membranes In A Rheb-Dependent Process In Absence Of NutrientsIn Response To NutrientsThe Complex Dissociates From Lysosomal Membranes And Relocalizes To The Cytosol |
| Alternative Antibody Names | Anti-Tbc1 Domain Family Member 7 antibodyAnti-Cell Migration-Inducing Protein 23 antibodyAnti-TBC1D7 antibodyAnti-TBC7 antibodyAnti-HSPC239 antibody |
Information sourced from Uniprot.org
