| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TBC1 domain family member 7 (85-135 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TBC1D7 |
| Gene ID: |
107080638/51256 |
| Uniprot ID: |
TBCD7_HUMAN |
| Immunogen Region: |
85-135 aa |
| Specificity: |
This antibody detects endogenous levels of TBCD7 at Human/Mouse |
| Immunogen: |
Synthesized peptide derived from the human TBCD7 at the amino acid range 85-135 |
| Function | Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth. The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling. The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1. |
| Protein Name | Tbc1 Domain Family Member 7Cell Migration-Inducing Protein 23 |
| Database Links | Reactome: R-HSA-8854214 |
| Cellular Localisation | Lysosome MembraneCytoplasmic VesicleCytoplasmCytosolLocalizes In The Cytoplasmic Vesicles Of The Endomembrane In Association With The Tsc-Tbc ComplexRecruited To Lysosomal Membranes In A Rheb-Dependent Process In Absence Of NutrientsIn Response To NutrientsThe Complex Dissociates From Lysosomal Membranes And Relocalizes To The Cytosol |
| Alternative Antibody Names | Anti-Tbc1 Domain Family Member 7 antibodyAnti-Cell Migration-Inducing Protein 23 antibodyAnti-TBC1D7 antibodyAnti-TBC7 antibodyAnti-HSPC239 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
