| Host: | Rabbit |
| Applications: | IHC/WB |
| Reactivity: | Human/Mouse/Rat/Marmoset |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-TAS2R46 is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Lyophilised |
| Purification: | IgG purified |
| Dilution Range: | IHC, WB. A dilution of 1:1000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | TAS2R46 |
| Gene ID: | 259292 |
| Uniprot ID: | T2R46_HUMAN |
| Specificity: | Specific for TAS2R46. |
| Immunogen: | A synthetic peptide from human TAS2R46 conjugated to blue carrier protein was used as the antigen. |
| Function | Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5. In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency. |
| Protein Name | Taste Receptor Type 2 Member 46T2r46Taste Receptor Type 2 Member 54T2r54 |
| Database Links | Reactome: R-HSA-418594Reactome: R-HSA-420499Reactome: R-HSA-9717207 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinCell ProjectionCilium MembraneIn Airway Epithelial CellsLocalizes To Motile Cilia |
| Alternative Antibody Names | Anti-Taste Receptor Type 2 Member 46 antibodyAnti-T2r46 antibodyAnti-Taste Receptor Type 2 Member 54 antibodyAnti-T2r54 antibodyAnti-TAS2R46 antibody |
Information sourced from Uniprot.org