| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-STRA6 (538-667) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
STRA6 |
| Gene ID: |
64220 |
| Uniprot ID: |
STRA6_HUMAN |
| Immunogen Region: |
538-667 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 538-667 of human STRA6 (NP_071764.3). |
| Immunogen Sequence: |
LYNAIHLGQMDLSLLPPRAA TLDPGYYTYRNFLKIEVSQS HPAMTAFCSLLLQAQSLLPR TMAAPQDSLRPGEEDEGMQL LQTKDSMAKGARPGASRGRA RWGLAYTLLHNPTLQVFRKT ALLGANGAQP |
| Tissue Specificity | Broad expression. In adult eye expressed in sclera, retina, retinal pigment epithelium, and trabecular meshwork but not in choroid and iris. |
| Post Translational Modifications | Phosphorylated on tyrosine residues in response to RBP4 binding. Phosphorylation requires the presence of LRAT, suggesting it may be triggered by the uptake of retinol that is then metabolized within the cell to retinoids that function as signaling molecules. |
| Function | Functions as retinol transporter. Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1. Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A. Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT-dependent generation of retinol metabolites that then trigger activation of JAK2 and its target STAT5, and ultimately increase the expression of SOCS3 and inhibit cellular responses to insulin. Important for the homeostasis of vitamin A and its derivatives, such as retinoic acid. STRA6-mediated transport is particularly important in the eye, and under conditions of dietary vitamin A deficiency (Probable). Does not transport retinoic acid. |
| Protein Name | Receptor For Retinol Uptake Stra6Retinol-Binding Protein Receptor Stra6Stimulated By Retinoic Acid Gene 6 Protein Homolog |
| Database Links | Reactome: R-HSA-2453864Reactome: R-HSA-2453902 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinIn The Retinal Pigment Epithelium Localizes To The Basolateral Membrane |
| Alternative Antibody Names | Anti-Receptor For Retinol Uptake Stra6 antibodyAnti-Retinol-Binding Protein Receptor Stra6 antibodyAnti-Stimulated By Retinoic Acid Gene 6 Protein Homolog antibodyAnti-STRA6 antibodyAnti-PP14296 antibodyAnti-UNQ3126 antibodyAnti-PRO10282 antibodyAnti-PRO19578 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
