| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Protein phosphatase Slingshot homolog 1 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SSH1 |
| Gene ID: | 54434 |
| Uniprot ID: | SSH1_HUMAN |
| Specificity: | This antibody detects endogenous levels of Slingshot homolog 1/SSH1 at Human, Mouse |
| Immunogen: | Synthesized peptide derived from human Slingshot homolog 1/SSH1 |
| Function | Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. |
| Protein Name | Protein Phosphatase Slingshot Homolog 1Ssh-Like Protein 1Ssh-1lHssh-1l |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionLamellipodiumCleavage FurrowMidbodyAlso Recruited To Actin Rich Membrane Protrusions Such As LamellipodiaWhich May Allow Local Control Of Actin Dynamics At Sites Of Cell LocomotionAlso Localized To The Cleavage Furrow And The Midbody During Cytokinesis |
| Alternative Antibody Names | Anti-Protein Phosphatase Slingshot Homolog 1 antibodyAnti-Ssh-Like Protein 1 antibodyAnti-Ssh-1l antibodyAnti-Hssh-1l antibodyAnti-SSH1 antibodyAnti-KIAA1298 antibodyAnti-SSH1L antibody |
Information sourced from Uniprot.org