• Western blot analysis of the lysates from K562 cells using SRY antibody.
  • Western blot analysis of lysates from HeLa cells, using SRY Antibody. The lane on the right is blocked with the synthesized peptide.

Anti-SRY antibody (51-100 aa) (STJ95789)

SKU:
STJ95789

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Sex-determining region Y protein (51-100 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:20000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SRY
Gene ID: 6736
Uniprot ID: SRY_HUMAN
Immunogen Region: 51-100 aa
Specificity: SRY Polyclonal Antibody detects endogenous levels of SRY protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human SRY at the amino acid range 51-100
Function Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-ATAACAAAT-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons.
Protein Name Sex-Determining Region Y Protein
Testis-Determining Factor
Database Links Reactome: R-HSA-3769402
Reactome: R-HSA-9690406
Cellular Localisation Nucleus Speckle
Cytoplasm
Nucleus
Acetylation Contributes To Its Nuclear Localization And Deacetylation By Hdac3 Induces A Cytoplasmic Delocalization
Colocalizes With Sox6 In Speckles
Colocalizes With Caml In The Nucleus
Colocalizes In The Nucleus With Znf208 Isoform Krab-O And Tyrosine Hydroxylase (Th)
Nuclear Import Is Facilitated By Xpo4
A Protein That Usually Acts As A Nuclear Export Signal Receptor
Alternative Antibody Names Anti-Sex-Determining Region Y Protein antibody
Anti-Testis-Determining Factor antibody
Anti-SRY antibody
Anti-TDF antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance